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CerefolinNAC® was replaced by Cerefolin Brain Wellness™, which is the same great product with the same trusted effectiveness, but without major allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame and soy), dyes and colorants. We changed the name because we made the product more accessible to those who want or need it. It’s now available online in 30 day and 60 day supply packages without needing a prescription. Because we know healthcare providers will continue prescribing Cerefolin Brain Wellness™ to their patients, too, it’s also available by prescription in a 90 day supply.

Cerefolin Brain Wellness™, previously known and studied as CerefolinNAC®, is the same trusted and effective product that is now free from, dyes, colorants, and major allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame and soy). Now you can get the benefits without a prescription or, if needed, with a prescription through your healthcare provider.

Targeted nutrition are medical foods specially formulated with active (bioavailable) nutrients you cannot get through diet alone to meet the distinct nutritional requirements to address a certain condition—in this case, mild cognitive impairment (MCI). A medical food should be taken under medical supervision.

Cerefolin Brain Wellness™ is a targeted nutrition product for use under medical supervision for the clinical dietary management of mild cognitive impairment in patients with hyperhomocysteinemia (high homocysteine blood levels). It is specially formulated to meet the distinctive nutritional requirements for this condition.

Dietary ingredients include: 6 mg of L-Methylfolate calcium (active folate), 2 mg Methylcobalamin (Vitamin B12), and 600 mg N-Acetyl-l-cysteine (NAC). All ingredients: N-Acetyl-l-cysteine (NAC), Microcrystalline Cellulose and Silicon Dioxide, Hypromellose, L-Methylfolate Calcium, Magnesium Stearate (NF, Vegetable Source), Methylcobalamin.

Manufactured in the USA with high-quality ingredients sourced both in the U.S. and globally.

L-Methylfolate is an active folate, which means your body can absorb it and make use of it without having to take additional steps to break it down and activate it. L-Methylfolate may affect certain chemicals in the brain important for memory, cognitive function and brain health. It helps address underlying imbalances to help you retain your ability to learn, understand, and remember.

Cerefolin Brain Wellness™ works by providing essential nutrients for brain health, that help to manage memory loss symptoms. The three nutrients include:

• L-Methylfolate, the active form of folate that supports memory and focus-related neurotransmitter production, while improving brain metabolism.⁵

• N-Acetyl-l-cysteine (NAC) contributes to brain health by reducing oxidative stress. ¹⁰

• Methylcobalamin boosts energy production to support overall brain function.⁹

These ingredients efficiently decrease homocysteine levels, which over time can help limit blood vessel damage and brain shrinkage linked to cognitive decline.

The ingredients in Cerefolin Brain Wellness™ are formulated for dual action in the brain: 

1. Improves brain health, memory, focus and concentration

2. Slows cognitive decline and brain atrophy

Cerefolin Brain Wellness™ began as a targeted nutrition product sold by prescription and is recommended by neurologists* to address the early signs of mild cognitive decline, protecting memory and cognitive function. The ingredients in Cerefolin Brain Wellness™ are different from the ingredients found in most folic acid supplements.  Its formula provides the body with already-active folate (which means it can be absorbed and immediately used by the body because it doesn’t need to be broken down or activated), N-Acetyl-l-cysteine, and B12 that the body needs to address symptoms of mild cognitive impairment (MCI). Most folic acid products need to be broken down in the body before the folate can be used, and many people may not be able to fully complete this activation.

The dietary ingredients in Cerefolin Brain Wellness™ have been shown in multiple studies* to support memory, brain health and cognitive function. In a real-world study with patients with high homocysteine levels and memory loss, Cerefolin Brain Wellness™ delayed brain atrophy up to 11.2 times better than patients not taking Cerefolin Brain Wellness™ and significantly improved quality of life scores. Other clinical studies showed Cerefolin Brain Wellness™ supports memory retention and executive function (thinking, decision making), helping patients maintain focus and perform memory-related tasks.^1-4

Yes, you can buy Cerefolin Brain Wellness™ without a prescription in a 30 and 60 day supply. However, you should inform your healthcare provider as targeted nutrition is meant to be used under medical supervision. See our product page for details.

Yes. Cerefolin Brain Wellness™ is targeted nutrition for use under medical supervision. While you can buy it directly, you should tell your healthcare provider you are using it and follow their advice.

If you are noticing changes in memory or thinking and are concerned about mild cognitive decline, talk to your healthcare provider and try Cerefolin Brain Wellness™. Cerefolin Brain Wellness™ is targeted nutrition that can address certain nutrient imbalances in the brain and help you retain your ability to learn, remember, and understand, and protect this cognitive function longer than going without it. Everyone is different, so results can vary and it will take some time to work.

Some people notice results in as little as 45 days, but timing and results vary. We typically recommend people take it for at least 12 weeks to start noticing results.

Long-term use of Cerefolin Brain Wellness™ can continue to help support your cognitive health. Cerefolin Brain Wellness™ is supported with over 7 years of clinical data. As with any medical food, talk with your healthcare provider first before stopping Cerefolin Brain Wellness™*.

It is typically safe to take Cerefolin Brain Wellness™ with other cognitive therapies and other medications, but it is always smart to talk to your healthcare provider to be sure.

Cerefolin Brain Wellness™ is contraindicated in patients with known hypersensitivity to any of the components contained in this product.

You can buy Cerefolin Brain Wellness™ in a 30 day and 60 day supply through our website or on Amazon. A 90 day supply is also available by prescription from Brand Direct Health® Pharmacy only.

There is not yet an Alfasigma USA, Inc. offered savings program for buying non-prescription Cerefolin Brain Wellness™ but, if you fill a prescription for Cerefolin Brain Wellness™ through Brand Direct Health® Pharmacy, you will receive an everyday low price along with exceptional customer service every step of the way.

The ingredients in Cerefolin Brain Wellness™* have been tested in many clinical studies. In addition, we have clinical data on patients we have followed for over 7 years, plus an MRI study that showed using Cerefolin Brain Wellness™* for over 2 years showed a rate of brain shrinkage 11.2 times slower than those not taking it.¹ Our healthcare provider pages provide more detail.

Improves Brain Health, Memory, Focus and Concentration:

• Supports acetylcholine and glutathione production^{5, 10, 11}
• Enhances vascular blood flow and cellular regeneration^{9, 12-14}
• Lowers elevated homocysteine levels^{1, 2}
• Clinical studies show Cerefolin Brain Wellness™* supports memory retention and executive function, helping patients maintain focus and perform memory-related tasks.^2-4
• People taking Cerefolin Brain Wellness™* for at least one year can significantly slow the progression of memory decline.^{2, 3}

Slows Cognitive Decline & Brain Atrophy:

• Cerefolin Brain Wellness™* has been shown to slow the progression of cognitive decline, helping patients maintain essential cognitive function longer.²
• A study revealed Cerefolin Brain Wellness™* can slow brain atrophy by up to 11.2 times compared to patients not taking Cerefolin Brain Wellness™, preserving brain health in those at risk of cognitive decline.¹

Cerefolin Brain Wellness™ is manufactured and distributed by Alfasigma USA, Inc. in Shreveport, LA.

Mild cognitive decline, also called MCI, is a condition in which some older adults have more memory loss or thinking problems than other people their age. They may notice these changes, but they typically are not bad enough to affect normal everyday activities.

Forgetting things here and there can be a normal part of aging, but symptoms of MCI typically happen more often but do not yet impact everday activities. MCI symptoms include:

• Forgetting to go to events and appointments
• Losing things often
• Having trouble coming up with words more than other people your age
• Losing your train of thought or having difficulty following a conversation
• Finding it hard to make decisions or follow instructions
• Getting lost in familiar surroundings

If you’re noticing changes in memory or thinking in yourself or in a loved one, it’s time to talk to a healthcare provider. They can perform tests—such as testing to see if you have elevated homocysteine levels—to assess whether you have MCI or another condition. Sometimes other health issues can cause similar memory or thinking problems, so it’s always good to get checked out, if you are noticing changes.