Improve Brain Health & Memory | Cerefolin Brain Wellness®

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Cerefolin Brain Wellness bottle and packaging on a white background — Neurologist recommended^5**

Targeted Nutrition to Slow Cognitive Decline and Brain Shrinkage^1,3

Improve Brain Health, Memory, Focus & Concentration

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Cerefolin Brain Wellness® is a medical food for the clinical dietary management of mild cognitive impairment with hyperhomocysteinemia and is specially formulated to meet the distinctive nutritional requirements for this condition. Use under medical supervision.

When Little Slips Start Adding Up

Everyone forgets things now and then — a name, a date, where you left your keys. But when those slips start to happen more often, or daily life feels a little harder, it might be worth bringing up with your healthcare provider. Some additional signs you may notice include:

Missing appointments often

Struggling to find words

Frequently losing things

Losing train of thought

Having trouble deciding

Getting lost in familiar places

Learn More

Cerefolin brain wellness supplement bottle with 'Dual Action' text and arrows on a white background

Dual Action Formula

Targeted nutrition for Mild Cognitive Impairment (MCI) with elevated homocysteine levels. Learn more about homocysteine here.

Improves

Brain Health

Cerefolin Brain Wellness® helps support overall brain function by providing essential nutrients that aid in reducing harmful homocysteine levels, which can negatively impact brain health.^3*
Memory & Focus

Individuals taking Cerefolin Brain Wellness® showed improvement in memory and ability to focus on daily activities.^4*
Concentration

Cerefolin Brain Wellness® helped people maintain attention and stay on task, which are essential for completing daily tasks and decision-making processes.^4*

Slows

Cognitive Decline

Long-term use of Cerefolin Brain Wellness® was associated with a significantly slower rate of cognitive decline, especially in individuals with mild cognitive impairment.^2*
Brain Atrophy

Research shows that people with mild cognitive impairment (MCI) and elevated homocysteine who took Cerefolin Brain Wellness® experienced slower brain shrinkage — helping support memory, thinking skills, and overall brain health.^1*

Use under medical supervision

Cerefolin brain wellness supplement bottle with blue cap on a white background

Trust in the Results

Neurologists recommend Cerefolin Brain Wellness®*. Starting early can help protect your brain cells, slow the loss of brain function, and improve your overall quality of life.^1-3

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Clinically Tested To

Slow the rate of brain shrinkage up to 11.2x^1*

Strong Loyalty

94% who used product for 90 days said they planned to continue⁴*

Free From

Gluten, dyes, sugar, sodium, caffeine, preservatives, GMOs, titanium dioxide and major food allergens*

You may start seeing improvements in as little as 45 days.

What people are saying^§||*

Individual results may vary.

Woman with short hair and glasses taking a selfie outdoors, with a 'Tressie' name overlay. — “I'm very appreciative of your wonderful service and also your great product.” “I recommend it to everybody.”
-Tressie

Man with gray hair and beard wearing a gray jacket, standing outdoors with greenery in the background. — “Those things really work.” “I'm not going to the refrigerator looking for ketchup and forgetting what I went to it for.” - George

Woman with curly hair smiling, with a blurred background and 'Monica' label. — “I believe that CerefolinNAC®* helped me tremendously with my day to day thinking.”
- Monica

Couple taking a selfie in front of a historical archway. — “I am feeling improvements from taking CerefolinNAC®*.” “We have many good years ahead of us to enjoy the active lives we lead.”
-Tessa

Man in a blue shirt smiling in a room with shelves and a couch. — “This has been a night and day difference. I feel like myself again.”
- Roland

Woman taking a selfie in a gym, wearing a watch. — “I am doing much better.”
- Laura

Woman taking a selfie outdoors with a blurred background — “I used to forget things a lot, but still a little, but not like before. Before it was terrible. I would even cry. I would get frustrated because my forgetfulness was so bad.”
-Cecelia

How to Make Sure the Cerefolin Brain Wellness® Product You’re Buying Is Real

Disclaimers

Cerefolin Brain Wellness® is a medical food for the clinical dietary management of mild cognitive impairment with hyperhomocysteinemia and is specially formulated to meet the distinctive nutritional requirements for this condition. Use under medical supervision.

**Based on prescriptions written by neurologists as a proxy for recommendation. In a 2025 survey conducted by Zappi, 93% of consumers surveyed indicated a doctor prescribing a product is a recommendation.

§ Images don’t portray actual consumers and are for illustration purposes only.

|| Testimonials based on experience with CerefolinNAC®*.

* Cerefolin Brain Wellness®, formerly known and studied as CerefolinNAC®, is the same trusted and effective product that is now free from major allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame and soy), dyes, and colorants.

† By submitting this information, I hereby give Alfasigma USA, Inc. authorization to release, reproduce, use or distribute information about me, in original or modified form, for promotional and educational purposes in all forms of media, including print, broadcast or Internet. This information may include my medical information if I choose to submit any. I understand my information may be shared with a third party working on Alfasigma USA, Inc.’s behalf for promotional or educational purposes. I also understand that I may be contacted by this third party or Alfasigma USA, Inc. for more information.

^†† This product should be taken under medical supervision, and you should consult your healthcare provider before taking this for mild cognitive impairment.

References

Shankle WR, et al. J Alzheimers Dis. 2016;54(3):1073-1084.
Shankle WR, et al. J Aging Res Clin Pract. 2013;2.
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Alfasigma USA, Inc. Support data. Data on file. 2019-2024.
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de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Int J Geriatr Psychiatry. 2012;27(6):592-600.
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Reynolds EH. BMJ. 2000;320(7248):1512-1515.
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Sah RP, et al. Ann Geriatr Med Res. 2023;27(4):370-380.
Rogers JD, Sanchez-Saffon A, Frol AB, Diaz-Arrastia R. Arch Neurol. 2003;60(1):59-64.
Smith AD, Refsum H. J Alzheimers Dis. 2016;54(4):1149-1166.
Seshadri S, Beiser A, Selhub J, et al. N Engl J Med. 2002;346(7):476-483.
Yao Y, Wang J, Wang J, et al. J Geriatr Cardiol. 2017;14(1):49-55.
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Keller AC, Kane MA, Heinze-Milne S, et al. J Appl Physiol. 2019;126(2):379-387.
Zhu Y, Liu J, Wang Y, et al. Climacteric. 2020;23(3):274-281.
Estrada DA, Ismail-Beigi F. Am J Hematol. 2001;67(3):221-227.
Luzzi S, D’Agostino V, Orlandi A, et al. Biomedicines. 2022;10(8):1892.
Diekman MJ, Anghelescu N, Endert E. Clin Endocrinol (Oxf). 2001;54(5):631-636.
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Myles PS, Leslie K, McNeil J, Forbes A, Chan MTV. Br J Anaesth. 2008;100(5):635-643.
Fallah S, Nouroozi V, Seifi M, Samadikuchaksaraei A. J Clin Lab Anal. 2012;26(5):360-365.
Lerman LO, Chade AR. Am J Physiol Heart Circ Physiol. 2022;322(4):H709-H720.
Troen AM, Shea-Budgell MA, Shukitt-Hale B, et al. Proc Natl Acad Sci U S A. 2008;105(34):12474-12479.
Hajj Mouhamed D, Ezzaher A, Neffati F, et al. Clin Chem Lab Med. 2011;49(6):987-993.
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Xu M, Zhang Y, Liu Y, et al. Nutr Neurosci. 2023;26(6):417-430.
Sohouli MH, et al. Nutr Rev. 2023;82(6):726-737.

ALUSA-01273

Targeted Nutrition to Slow Cognitive Decline and Brain Shrinkage1,3